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Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
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Stabilization of starch-based microgel-lysozyme complexes using a layer-by-layer assembly technique.

Bao Zhang1, Yi Pan1, Hanqing Chen1

  • 1School of Food Science and Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China.

Food Chemistry
|August 11, 2016
PubMed
Summary
This summary is machine-generated.

This study optimized chitosan (CS) and carboxymethyl starch (CMS) microgels for drug delivery. The findings suggest these stabilized microgels can effectively target intestinal delivery by preventing premature stomach release.

Keywords:
CMSChitosanLayer-by-layer assemblyStarch-based microgels

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Area of Science:

  • Materials Science
  • Biotechnology
  • Drug Delivery Systems

Background:

  • Developing effective drug delivery systems is crucial for targeted therapy.
  • Microgels offer potential as carriers due to their tunable properties.
  • Polyelectrolyte multilayers can enhance microgel stability and functionality.

Purpose of the Study:

  • To investigate the layer-by-layer assembly of chitosan (CS) and carboxymethyl starch (CMS) on responsive microgels.
  • To determine the optimal parameters for creating stable CS-CMS microgel complexes.
  • To evaluate the in vitro release of lysozyme from these stabilized microgels for targeted intestinal delivery.

Main Methods:

  • Confocal laser scanning microscopy (CLSM) for visualizing CS distribution.
  • Zeta potential measurements to determine optimal CS and CMS ratios.
  • In vitro release studies under simulated gastric and intestinal conditions.

Main Results:

  • Optimal CS molecular weight for surface absorption was 100 kDa.
  • Optimal weight ratios of CS and CMS to microgels were 0.1 and 0.06, respectively.
  • Stabilized double-layer microgel complexes demonstrated potential for preventing early release in the stomach.

Conclusions:

  • The optimized CS-CMS microgel system shows promise for controlled drug release.
  • This system facilitates targeted delivery to the intestines by modulating release profiles.
  • Further development could lead to advanced oral drug delivery platforms.