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Related Concept Videos

The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Related Experiment Video

Updated: Mar 16, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Iodine 125 Seed for Localization in Primary Hyperparathyroidism.

Sophie J R de Danschutter1, Jennifer M J Schreinemakers2, Peter A M Kint2

  • 1Amphia Hospital, Breda, the Netherlands sophie.dedanschutter@gmail.com.

Surgical Innovation
|August 11, 2016
PubMed
Summary

Iodine-125 seeds offer a safe method for preoperative localization of parathyroid glands before minimally invasive parathyroidectomy. This pilot study found the technique feasible, aiding in diseased gland identification for primary hyperparathyroidism surgery.

Keywords:
endocrine surgeryimage-guided surgerythyroid surgery

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Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Nuclear Medicine

Background:

  • Accurate preoperative localization of parathyroid glands is crucial for successful minimally invasive parathyroidectomy (MIP) due to anatomical variations.
  • Several localization methods exist, with iodine-125 (I-125) seeds emerging as a novel marker technique.

Purpose of the Study:

  • To evaluate the feasibility and safety of using an I-125 seed for preoperative localization of diseased parathyroid glands.
  • To assess the utility of I-125 seed localization in guiding minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism (PHPT).

Main Methods:

  • A pilot study involving 10 patients diagnosed with primary hyperparathyroidism (PHPT) and one enlarged parathyroid gland.
  • Preoperative ultrasound-guided placement of an I-125 seed into the affected parathyroid gland.
  • Evaluation of placement feasibility, intraoperative localization accuracy, and complication rates.

Main Results:

  • Ultrasound-guided I-125 seed placement was technically feasible in most patients.
  • Placement challenges occurred in 2 cases due to anatomical location, potentially affecting marker accuracy.
  • Minimally invasive parathyroidectomy (MIP) proceeded without major complications, with intraoperative bleeding being the primary concern.

Conclusions:

  • Iodine-125 (I-125) seed localization is a relatively safe technique for parathyroid surgery in primary hyperparathyroidism (PHPT).
  • Further research is warranted to compare the efficacy of I-125 seed localization with existing preoperative localization methods.