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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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The expanding regulatory universe of p53 in gastrointestinal cancer

Andrew Fesler1, Ning Zhang2, Jingfang Ju1

  • 1Translational Research Laboratory, Department of Pathology, Stony Brook University, Stony Brook, USA.

F1000Research
|August 11, 2016
PubMed

Insights

The tumor suppressor gene TP53 interacts with non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). This interaction is crucial for understanding gastrointestinal cancer biology and developing new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • The TP53 gene, a critical tumor suppressor, is frequently altered in gastrointestinal cancers.
  • p53 functions as a transcription factor, regulating genes involved in cell cycle, apoptosis, and DNA repair.
  • p53 also influences non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are implicated in cancer.

Purpose of the Study:

  • To review the current understanding of non-coding RNAs within the p53 regulatory network.
  • To explore the implications of these non-coding RNAs in gastrointestinal cancer biology.

Main Methods:

  • Literature review of studies on TP53, miRNAs, lncRNAs, and gastrointestinal cancer.
  • Analysis of the regulatory interactions between p53 and non-coding RNAs.
  • Synthesis of current knowledge on the role of non-coding RNAs in p53-mediated cancer pathways.

Main Results:

  • p53 directly regulates the expression of numerous miRNAs and interacts with lncRNAs.
  • Both miRNAs and lncRNAs function as tumor suppressors or oncogenes by targeting mRNAs.
  • The interplay between p53 and non-coding RNAs significantly impacts cellular functions and cancer development.

Conclusions:

  • Non-coding RNAs are integral components of the p53 regulatory network.
  • Understanding these interactions provides novel insights into gastrointestinal cancer pathogenesis.
  • Targeting the p53-non-coding RNA axis holds potential for future cancer therapies.
Keywords:
gastrointestinal cancernon-coding RNAp53

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