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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Hematopoiesis01:21

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Long noncoding RNAs in hematopoiesis.

Xu Zhang1, Wenqian Hu1

  • 1Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA.

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Summary
This summary is machine-generated.

Long noncoding RNAs regulate gene expression during mammalian development. This review summarizes their roles in hematopoiesis and suggests future research directions for these important non-protein-coding transcripts.

Keywords:
gene expressionhematopoiesisnoncoding RNAs

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Genetics

Background:

  • Mammalian development relies on precise gene expression control.
  • Long noncoding RNAs (lncRNAs) represent a newly discovered regulatory mechanism.
  • lncRNAs are transcripts >200nt lacking protein-coding potential and are often cell-type specific.

Purpose of the Study:

  • To review recent findings on lncRNAs in mammalian hematopoiesis.
  • To discuss the functional significance of lncRNAs in cell differentiation.
  • To offer perspectives on future research in this area.

Main Methods:

  • Literature review of recent studies on lncRNAs and hematopoiesis.
  • Analysis of lncRNA specificity across mammalian cell types and developmental stages.
  • Synthesis of current knowledge and identification of research gaps.

Main Results:

  • lncRNAs are increasingly recognized for their regulatory roles in gene expression.
  • Hematopoiesis, a well-studied differentiation process, provides a model for lncRNA function.
  • Specific lncRNAs are expressed during distinct stages of blood cell development.

Conclusions:

  • lncRNAs play crucial roles in the complex process of mammalian hematopoiesis.
  • Further investigation is needed to fully elucidate lncRNA functions in development.
  • Future studies should focus on the specific mechanisms and therapeutic potential of lncRNAs.