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Altered relation of the renin-aldosterone system and vasoactive peptides in type 2 diabetes: The KORA F4 study

Cornelia Then1, Marietta Rottenkolber2, Andreas Lechner1

  • 1Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität, Munich, Germany; Clinical Cooperation Group Diabetes, Ludwig-Maximilians-Universität München and Helmholtz Zentrum München, Munich, Germany.

Atherosclerosis
|August 11, 2016
PubMed
Abstract

Insights

Renin and aldosterone levels show altered associations with vasoactive peptides in type 2 diabetes. These hormones are not independent biomarkers for early atherosclerosis in the general population.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Metabolic Diseases

Background:

  • Premature atherosclerosis in diabetes remains mechanistically unclear.
  • The renin-aldosterone-angiotensin system's inappropriate activation is a potential cardiovascular disease risk factor.
  • Vasoactive peptides, midregional-pro atrial natriuretic peptide (MR-proANP) and midregional-pro adrenomedullin (MR-proADM), are relevant markers.

Purpose of the Study:

  • To investigate associations between renin, aldosterone, and vasoactive peptides (MR-proANP, MR-proADM).
  • To examine the relationship between renin, aldosterone, and intima media thickness (IMT) as a marker of early atherosclerosis.
  • To compare these associations in the general community versus individuals with type 2 diabetes.

Main Methods:

  • Analysis of 1261 participants from the KORA F4 study.
  • Stratified linear regression models were used to assess associations.
  • Adjustments were made for confounding factors.

Main Results:

  • In non-diabetic individuals, inverse associations were found between MR-proANP and renin/aldosterone, and direct associations between MR-proADM and renin/aldosterone.
  • In type 2 diabetes, no significant correlations were observed between MR-proANP/MR-proADM and renin/aldosterone.
  • Aldosterone was associated with IMT in diabetic participants, but renin and aldosterone were not associated with IMT in non-diabetic subjects or the total cohort.

Conclusions:

  • Associations between renin, aldosterone, and MR-proANP/MR-proADM plasma levels are altered in type 2 diabetes.
  • Plasma renin and aldosterone are not independent biomarkers for early atherosclerotic damage in carotid arteries within the general community.
Keywords:
ANPAdrenomedullinAldosteroneDiabetesMR-proADMMR-proANPRenin

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