Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

6.1K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.1K
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

1.2K
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
1.2K
Cell Migration01:09

Cell Migration

19.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.0K
Cell Migration01:19

Cell Migration

7.2K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.2K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.7K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

4.0K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinguishable spreading dynamics in microbial communities.

Biophysical journal·2026
Same author

Effects of cell-cell communication on bacterial chemotaxis.

Physical review. E·2026
Same author

Reply.

Gastroenterology·2026
Same author

Biomechanical 3D tumor models on a micro-milled high-throughput force sensor array.

Biofabrication·2026
Same author

Structure-functionality relationship of collagen-fibrin interpenetrating hydrogels for engineered tumor-stroma models.

Acta biomaterialia·2026
Same author

Fast, long-range intercellular signal propagation through growth-assisted positive feedback.

Cell systems·2026
Same journal

Enhanced-Sampling Simulations Reveal Distinct Intermediates in SARS-CoV-2 FSE Pseudoknot Interconversion.

Biophysical journal·2026
Same journal

Structure-based simulations of the full Flock House virus capsid reveal pathways and energetics of an infection-critical peptide externalization event.

Biophysical journal·2026
Same journal

Quantifying the Peripheral Surface Information Entropy from Conformational Ensembles of Globular Protein-Peptide Complexes.

Biophysical journal·2026
Same journal

Anisotropic unbinding and location-dependent hovering of a kinesin motor head over microtubule.

Biophysical journal·2026
Same journal

Kinesin-5/Cut7 C-terminal tail phosphorylation influence on motor regulation through multi-scale molecular modeling.

Biophysical journal·2026
Same journal

Dynamic conformations of fluorophores on self-labeling protein tags.

Biophysical journal·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.6K

Collective Chemotaxis through Noisy Multicellular Gradient Sensing.

Julien Varennes1, Bumsoo Han2, Andrew Mugler1

  • 1Department of Physics and Astronomy, Purdue University, West Lafayette, Indiana.

Biophysical Journal
|August 11, 2016
PubMed
Summary
This summary is machine-generated.

Cell clusters migrate efficiently by balancing precise chemical sensing with reduced drag. Our model reveals an optimal cluster size for collective cell migration, crucial for understanding biological processes.

More Related Videos

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.5K
Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

10.7K

Related Experiment Videos

Last Updated: Mar 16, 2026

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.6K
Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
10:40

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

Published on: November 9, 2017

7.5K
Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
08:24

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells

Published on: September 14, 2016

10.7K

Area of Science:

  • * Cellular biology and biophysics
  • * Quantitative biology and systems biology

Background:

  • * Collective cell migration is vital for development and disease, with cells sensing minute chemical gradients (<1%).
  • * Understanding how multicellular systems translate environmental sensing into coordinated migration is a key challenge.

Purpose of the Study:

  • * To develop a computational model for multicellular sensing and migration.
  • * To investigate how cluster size influences gradient detection and migratory efficiency.

Main Methods:

  • * Development of a computational model simulating collective cell sensing of chemical gradients.
  • * Numerical simulations to analyze the relationship between cluster size, gradient precision, and migration dynamics.

Main Results:

  • * Larger cell clusters offer higher gradient detection precision but experience increased drag.
  • * A trade-off exists between sensing accuracy and migratory drag, defining an optimal cluster size.
  • * Model predicts an optimal cluster size for the most efficient collective cell migration.

Conclusions:

  • * The study identifies an optimal cluster size for efficient collective cell migration.
  • * Findings provide insights into the biophysical mechanisms linking sensing to migration.
  • * The model offers a framework for experimental validation in biological systems.