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Evaluation of Cardiovascular Risk Factors, Haematological and Biochemical Parameters, and Serum Endocan Levels in
Emin Ozlu1, Ayse Serap Karadag, Aybala E Toprak
1Department of Dermatology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Insights
Serum endocan levels are unchanged in lichen planus (LP) patients. However, LP patients show distinct differences in specific haematological and biochemical parameters compared to healthy individuals.
Area of Science:
- Dermatology
- Cardiovascular Medicine
- Hematology
Background:
- Lichen planus (LP) is an inflammatory condition with potential systemic implications.
- Cardiovascular risk factors and specific biomarkers are increasingly studied in relation to LP.
- Endocan, a potential biomarker, has not been extensively evaluated in LP patients.
Purpose of the Study:
- To investigate cardiovascular risk factors, haematological and biochemical profiles, and serum endocan levels in lichen planus (LP) patients.
- To compare these parameters between LP patients and healthy controls.
Main Methods:
- A case-control study involving 43 LP patients and 43 healthy controls.
- Evaluation of cardiovascular risk factors, routine haematological and biochemical parameters.
- Measurement of serum endocan concentrations.
Main Results:
- Serum endocan concentrations did not significantly differ between LP patients and controls (p > 0.05).
- No significant differences in endocan levels were observed based on cardiovascular risk factors or smoking history.
- LP patients exhibited significantly higher white blood cell count, platelet distribution width, and monocyte count/HDL cholesterol ratios compared to controls (p < 0.05).
- Mean platelet volume was significantly lower in the LP group (p < 0.05).
Conclusions:
- Serum endocan levels are not significantly altered in lichen planus.
- Significant differences in specific haematological parameters (WBC, PDW, MPV, and monocyte/HDL ratio) are noted in LP patients.
Background And Objective:
The current study aimed to evaluate cardiovascular risk factors, haematological and biochemical parameters, and serum endocan concentrations in lichen planus (LP) patients.
Methods:
This study was conducted with 86 cases, including 43 LP patients and 43 healthy controls. Cardiovascular risk factors, haematological and biochemical parameters, and endocan levels were evaluated.
Results:
The serum endocan concentrations of LP patients were not significantly different from those of the healthy controls (p > 0.05). There were no significant differences in the serum endocan levels according to classification by cardiovascular risk factors and smoking history (p > 0.05). In the LP group, white blood cell count, platelet distribution width and monocyte count/high-density lipoprotein cholesterol ratios were significantly higher when compared to the healthy controls (p < 0.05). The LP group had a lower mean platelet volume than the healthy controls (p < 0.05).
Conclusions:
Serum endocan levels did not change significantly in patients with LP, and there were significant differences in haematological and biochemical parameters.
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