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Hospital-based Surveillance of Rotavirus Diarrhea among Under- five Children in Chandigarh
Madhu Gupta1, M P Singh, Vishal Guglani
1School of Public Health and Departments of *Virology, PGIMER; and Department of Pediatrics, GMCH and GMSH; Chandigarh, India madhugupta21@gmail.com.
Insights
Rotavirus is a common cause of acute gastroenteritis in young children. This study found that 18.8% of hospitalized children in Chandigarh had rotavirus, with G1P[8] being the most common genotype.
Area of Science:
- Pediatrics
- Virology
- Public Health
Background:
- Acute gastroenteritis is a significant cause of childhood morbidity globally.
- Rotavirus is a leading viral pathogen responsible for severe gastroenteritis in children under five.
- Hospital-based surveillance is crucial for understanding local epidemiology of infectious diseases.
Purpose of the Study:
- To determine the prevalence of rotavirus in children under five admitted with acute gastroenteritis in Chandigarh.
- To identify the common rotavirus genotypes circulating during the study period.
Main Methods:
- Prospective hospital-based surveillance conducted from May 2011 to July 2012.
- Collection and analysis of 239 stool samples from children under five with acute gastroenteritis.
- Detection of rotavirus antigen and genotyping using reverse transcriptase polymerase chain reaction (RT-PCR).
Main Results:
- Rotavirus antigen was detected in 18.8% of the collected stool samples.
- The most prevalent rotavirus genotypes identified were G1P[8] (53.3%) and G12P[6] (15.6%).
- Rotavirus genotype G3 was not detected in the analyzed samples.
Conclusions:
- Rotavirus is an important etiological agent of acute gastroenteritis in hospitalized children under five in Chandigarh.
- The study highlights the predominance of G1P[8] and G12P[6) genotypes, informing vaccine strategies.
- Continued surveillance is recommended to monitor rotavirus epidemiology and genotype distribution.
Abstract:
In a prospective hospital-based surveillance of 958 under five children admitted with acute gastroenteritis in Chandigarh (May 2011 to July 2012), 239 stool samples were collected. Rotavirus antigen was detected in 18.8% of samples by reverse transcriptase polymerase chain reaction. Genotypes G1P[8] (53.3%), G12P[6] (15.6%) were prevalent, and G3 not detected.