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Related Experiment Video

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How Body Affects Brain.

Wendy A Suzuki1

  • 1Center for Neural Science, New York University, New York, NY 10003, USA.

Cell Metabolism
|August 11, 2016
PubMed
Summary

Exercise releases a novel protein, cathepsin B (CTSB), from muscles. This myokine is linked to enhanced memory function, offering new insights into how physical activity benefits the brain.

Area of Science:

  • Neuroscience
  • Exercise Physiology
  • Molecular Biology

Background:

  • Physical exercise impacts brain function and cognition.
  • The peripheral signaling pathways mediating these effects remain largely unknown.

Purpose of the Study:

  • To investigate the role of peripheral signals in exercise-induced cognitive improvements.
  • To identify novel myokines associated with enhanced memory.

Main Methods:

  • The study by Moon et al. (2016) focused on identifying and characterizing novel myokines.
  • Investigated the release of cathepsin B (CTSB) during physical activity.
  • Assessed the association between CTSB levels and memory performance.

Main Results:

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  • A novel myokine, cathepsin B (CTSB), was identified.
  • CTSB is released from muscles during exercise.
  • Elevated levels of CTSB were correlated with improved memory function.

    • Conclusions:

    • Cathepsin B (CTSB) is a key peripheral signal linking exercise to cognitive benefits.
    • This finding opens new avenues for understanding exercise-induced neuroplasticity.
    • CTSB may represent a therapeutic target for cognitive enhancement.