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Updated: Mar 16, 2026
04:09
Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
3.9K
Team Approach: Treatment of Diabetic Foot Ulcer
Michael S Pinzur1, Harriet Cavanah Dart2, Richard C Hershberger1
1Loyola University Health System, Maywood, Illinois.
JBJS Reviews
|August 11, 2016
Summary
Diabetic foot ulcers affect 3-4% of US patients, leading to over 70,000 amputations annually. This review offers a framework for healthcare systems to manage this critical diabetes complication.
Area of Science:
- Podiatry
- Endocrinology
- Public Health
Background:
- Diabetes affects 9.3% of the US population, with 3-4% experiencing foot ulcers.
- Diabetic foot ulcers and infections cause over 70,000 lower-extremity amputations yearly.
- Major lower-extremity amputation in diabetic patients has a 2-year mortality rate of 33-50%.
Purpose of the Study:
- To provide a framework for developing health-care-system strategies.
- To address the complex issue of diabetic foot ulcers and their management.
- To reduce the incidence and severity of this diabetes comorbidity.
Main Methods:
- Review of existing multidisciplinary population health-management strategies.
- Analysis of the impact of diabetic foot ulcers on patient outcomes.
- Synthesis of information to create a strategic framework.
Main Results:
- Significant morbidity and mortality associated with diabetic foot ulcers.
- Identification of the need for comprehensive, system-level interventions.
- Development of a conceptual model for healthcare system strategy.
Conclusions:
- Effective management of diabetic foot ulcers requires a multidisciplinary approach.
- A structured health-care-system strategy is essential to reduce amputations and mortality.
- Implementing population health management can mitigate this significant diabetes comorbidity.
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