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Updated: Mar 16, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Transfusion Therapy in Children With Sickle Cell Disease
Adlette Inati1, Anthony G Mansour, Toni Sabbouh
1*Department of Pediatrics, Lebanese American University and University Medical Center Rizk Hospital, Beirut †School of Medicine, Lebanese American University, Byblos, Lebanon ‡Department of Molecular and Cellular Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX.
Abstract:
Hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation represent the 3 disease-modifying therapies in children with sickle cell disease (SCD). Blood transfusions play an increasingly important role in both prevention and management of SCD complications in this age group. This review will focus on the indications of blood transfusion in children with SCD and modalities of its administration. It will also highlight the complications of this life-saving therapy and ways of optimizing transfusion to minimize its associated risks.
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