Washing of platelets can be fully automated using a closed-system cell processor and BRS-A platelet additive solution

Area of Science:

• Transfusion Medicine
• Hematology
• Biotechnology

Background:

• Platelet (PLT) concentrates are critical for treating thrombocytopenia.
• Washing PLTs removes plasma proteins, reducing alloimmunization risk.
• Automated systems like Haemonetics ACP215 offer efficient PLT processing.

Purpose of the Study:

• To evaluate the in vitro properties of platelets washed with BRS-A additive solution.
• To compare two processing modes within the Haemonetics ACP215 system.
• To assess the impact of processing on platelet recovery and plasma protein removal.

Main Methods:

• Platelets were processed using the Haemonetics ACP215 system with BRS-A.
• Two groups were established: control (manual ACD-A addition) and test (automatic ACD-A addition).
• In vitro properties were assessed over 7 days of storage (n=7).

Main Results:

• Platelet recovery was high and comparable in both groups (86.2% vs 86.0%).
• Plasma protein removal was excellent and similar (98.8% vs 99.0%).
• No significant differences in in vitro properties were observed between the groups.

Conclusions:

• The Haemonetics ACP215 system with BRS-A effectively washes platelets.
• Manual and automatic processing modes yield comparable results for platelet quality.
• This processing method ensures high platelet recovery and efficient plasma protein removal.