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Related Experiment Videos

Maternofetal potential difference in pigs.

R D Boyd1, J D Glazier, C P Sibley

  • 1Department of Child Health, University of Manchester, St. Mary's Hospital, United Kingdom.

The American Journal of Physiology
|July 1, 1989
PubMed
Summary
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Maternal and fetal blood vessel potential difference (PD) in sows was measured. Fetal injections of epinephrine, isoprenaline, and phenylephrine altered PD, with beta-agonists showing a stronger effect than alpha-agonists.

Area of Science:

  • Physiology
  • Perinatal Medicine
  • Pharmacology

Background:

  • The maternofetal potential difference (PD) is crucial for placental function and fetal development.
  • Understanding catecholamine effects on maternofetal PD is vital for assessing fetal well-being during gestation.

Purpose of the Study:

  • To investigate the effects of catecholamines on the maternofetal potential difference (PD) in conscious pregnant sows.
  • To characterize the specific roles of alpha- and beta-adrenergic receptors in mediating these PD changes.

Main Methods:

  • Measurement of maternofetal PD in conscious sows (97-107 days gestation) using implanted catheters.
  • Intra-fetal injections of epinephrine, isoprenaline (beta-agonist), and phenylephrine (alpha-agonist).
  • Administration of propranolol (beta-antagonist) to assess its impact on epinephrine's effects.

Related Experiment Videos

  • High-performance liquid chromatography (HPLC) for fetal plasma epinephrine concentration analysis.

    • Main Results:

    • Resting maternofetal PD was measured as -18 +/- 4 mV, becoming more negative post-surgery.
    • Fetal epinephrine injections caused rapid, dose-dependent changes in PD, shifting it towards less negative or positive values.
    • Isoprenaline induced a significant PD change, while phenylephrine required a higher dose for a similar effect, indicating beta-receptor sensitivity.
    • Propranolol partially blocked the effect of epinephrine, confirming beta-receptor involvement.

    Conclusions:

    • Catecholamines, particularly via beta-adrenergic pathways, significantly influence maternofetal PD in late gestation sows.
    • The observed effects align with in vitro transplacental PD studies, suggesting conserved mechanisms.
    • An unexplained difference exists between resting maternofetal PD and transplacental PD, warranting further investigation.