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[ARID1A expression of SWI/SNF remodeling complex in pancreatic neuroendocrine tumor]
1Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
Objective:
To study ARID1A expression and its role in pancreatic neuroendocrine tumors.
Methods:
51 cases of pancreatic neuroendocrine tumors were collected from July 2003 to May 2012 from Peking Union Medical College Hospital.Eighteen normal pancreatic tissues were used as positive control. HE staining method was used to observe general clinicopathological features. ARID1A expression was detected immunohistochemically by EnVision method. The relationship between ARID1A expression and tumor grade and stage was analyzed.
Results:
The level of ARID1A expression was not associated with patients' gender, age, TNM stage, and tumor size (P>0.05); but showed significantly negative correlation with tumor grade (P<0.05).
Conclusions:
Low ARID1A expression was significantly related to the high grade level of pancreatic neuroendocrine tumors. It has a certain effect on the clinical classification of pancreatic neuroendocring tumors. ARID1A may play a role as a tumor suppressor gene.
