Related Experiment Video
Updated: Mar 16, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse
Published on: October 24, 2018
[Complications of critically ill children supported by venoarterial extracorporeal membrane oxygenation]
1Pediatric Intensive Care Unit, Children's Hospital of Fudan University, Shanghai 201102, China.
Insights
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) in critically ill children can lead to neurological, mechanical, and clotting complications. Careful management and teamwork are crucial for reducing these risks.
Area of Science:
- Pediatric Critical Care Medicine
- Cardiopulmonary Support
- Extracorporeal Membrane Oxygenation
Background:
- Critically ill children often require advanced life support.
- Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides essential cardiopulmonary support.
- Understanding complications is vital for patient outcomes.
Purpose of the Study:
- To investigate complications associated with VA-ECMO in critically ill children.
- To identify the types and frequencies of VA-ECMO complications.
- To inform strategies for mitigating risks.
Main Methods:
- Retrospective analysis of 25 critically ill children treated with VA-ECMO.
- Data collected from December 2011 to December 2015.
- Complications recorded during ECMO therapy via right internal carotid artery and jugular vein catheterization.
Main Results:
- Seventeen patients (68%) successfully weaned from ECMO; 15 (60%) survived to discharge.
- Thirty-three complications occurred, including 9 mechanical (e.g., oxygenator leakage, hemolysis) and 24 somatic complications.
- Neurological complications (n=8) and bleeding complications (n=8) were most frequent, alongside acute kidney injury (n=5) and microcirculation thrombosis (n=3).
Conclusions:
- VA-ECMO is associated with significant neurological, mechanical, and clotting complications.
- Advanced equipment, materials, and effective teamwork are essential for minimizing these risks.
- Optimizing VA-ECMO protocols can improve patient safety and outcomes.
Objective:
To study the complications occurred in the process of venoarterial extracorporeal membrane oxygenation (VA-EMCO) in critically ill children.
Method:
To analyze retrospectively 25 children who were admitted to PICU of Children's Hospital of Fudan University from December 2011 to December 2015. They were all treated with VA-ECMO with incision and catheterization in right internal carotid artery and jugular vein. Complications were recorded during ECMO process.
Result:
The duration of ECMO treatment was 14 to 567 h (153 (112, 204) h). Seventeen cases (68%) withdrew from ECMO successfully and 15 cases (60%) survived to discharge. Thirty-three complications occurred during ECMO treatment. Of which, mechanical complications occurred 9 times, including oxygenator leakage (n=3), hemolysis (n=2), water tank failure (n=2), pump head rupture (n=1) and piping thrombosis (n=1). Somatic complications appeared 24 times, including neurological complications (n=8) which included cerebral infarction (n=2), convulsions (n=2), intracranial hemorrhage (n=2), thrombosis after ligation of internal jugular vein (n=1) and cerebral atrophy (n=1); bleeding complications (n=8) which included bleeding at puncture sites (n=4), ECMO canalized site bleeding (n=3), and spontaneous (n=1), intracranial hemorrhage or hematoma cases(n=2) in mechanical complications; acute kidney injury (n=5) and microcirculation thrombosis (n=3).
Conclusion:
ECMO technique may cause complications, which mainly include neurological, mechanical and clotting complications. Advanced equipments and materials and well-managed teamwork are helpful in decreasing complications.
More Related Videos
03:40Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
Published on: January 17, 2025
07:41Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
Published on: July 20, 2022
Related Concept Videos
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Oxygen Delivering System II: Venturi Mask and Transtracheal Oxygen
Venturi Mask
The Venturi mask, named after the Venturi effect, is designed to deliver precise oxygen concentrations. It consists of a large tube with an oxygen inlet that narrows down, causing a pressure drop that pulls air in through adjustable side ports. The mask is a lightweight,...
Hemodialysis II: Procedure and Complications
Acute Respiratory Failure-III
Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...