Analysis of the influence of ¹¹¹In on ⁹⁰Y-bremsstrahlung SPECT based on Monte Carlo simulation

⁹⁰Y-ibritumomab tiuxetan (Zevalin) which is used for the treatment of malignant lymphomas can be used for SPECT imaging based on bremsstrahlung from ⁹⁰Y beta particles. However, gamma rays emitted by ¹¹¹In, which is administered to evaluate the indication for the treatment, contaminate the ⁹⁰Y bremsstrahlung images. Our objective is to investigate the influence of ¹¹¹In on the ⁹⁰Y SPECT images using Monte Carlo simulation.

We used an in-house developed simulation code for the Monte Carlo simulation of electrons and photons (MCEP). Two hot spheres with diameters of 40 mm were put in an elliptical phantom. Both spheres ("sphere 1" and "sphere 2") were filled with ⁹⁰Y and ¹¹¹In mixed solutions. The activities of ⁹⁰Y in sphere 1 and sphere 2 were 241 and 394 kBq/mL, respectively, and the ones of ¹¹¹In were 8.14 and 13.3 kBq/mL, respectively. The background activity of ⁹⁰Y was 38.6 kBq/mL, whereas that of ¹¹¹In was 1.30 kBq/mL; moreover, the acquisition time was 30 min. Two energy windows were used: one is 90-190 keV included the ¹¹¹In photopeak; the other is 90-160 keV. To evaluate the quality of the SPECT images, the contrast recovery coefficient (CRC) and the constant noise ratio (CNR) of the SPECT images were derived.

For the energy window between 90 and 160 keV, the ¹¹¹In count was 74 % of the total. In that case, the CRC values were 30.1 and 30.7 % for "sphere 1" and "sphere 2", respectively, whereas the CNR values were 6.8 and 12.1, respectively. For the energy window between 90 and 190 keV, the ¹¹¹In count reached 85 % of the total count. The CRC and CNR values were 38.6 and 40.0 % and 10.6 and 19.4, respectively.

Our simulation study revealed that the cross talk between ¹¹¹In and ⁹⁰Y in SPECT imaging is rather serious. Even for the energy window excluding the ¹¹¹In photopeak, the count ratio of ⁹⁰Y was less than 30 % of the total. However, the influence of ¹¹¹In on ⁹⁰Y-SPECT imaging cannot be ignored, and the count ratio because of ¹¹¹In is important to estimate the density of ⁹⁰Y.