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The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients

Nihal Özkayar1, Fatma Akyel1, Ayşe Nurdan Barça2

  • 1Department of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Turkish Journal of Medical Sciences
|August 12, 2016
PubMed

Insights

Higher serum cathepsin D levels correlate with increased carotid intima-media thickness (CIMT) in hypertensive individuals. This finding suggests cathepsin D may be a marker for vascular changes in hypertension.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Hypertension Studies

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Carotid intima-media thickness (CIMT) is an indicator of subclinical atherosclerosis.
  • Cathepsin D is a lysosomal protease implicated in various cellular processes.

Purpose of the Study:

  • To investigate the association between serum cathepsin D levels and CIMT.
  • To explore potential biomarkers for early vascular damage in hypertensive patients.

Main Methods:

  • Cross-sectional study of 74 hypertensive patients.
  • Serum cathepsin D levels measured using ELISA.
  • CIMT assessed via ultrasound of common and internal carotid arteries.

Main Results:

  • A significant positive correlation was observed between serum cathepsin D and CIMT (r = 0.331, P = 0.04).
  • Multivariate analysis identified cathepsin D, albumin, and hypertension duration as significant predictors of CIMT.

Conclusions:

  • Elevated serum cathepsin D is associated with increased CIMT in non-diabetic hypertensive patients.
  • Cathepsin D may serve as a potential biomarker for atherosclerosis progression in hypertension.
Abstract

Keywords:
Atherosclerosiscarotid intima-media thicknesscathepsin Dhypertension

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