Related Experiment Video

Updated: Mar 16, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

795

The relationship of mean platelet volume with microalbuminuriain type 2 diabetic patients

Seyit Murat Bayram1, Gül Gürsoy2, Aslı Araz Güngör1

  • 1Department of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey.

Turkish Journal of Medical Sciences
|August 12, 2016
PubMed
Abstract

Insights

Mean platelet volume (MPV) is elevated in type 2 diabetes patients, particularly those with microalbuminuria. Higher MPV levels correlate with microalbuminuria, suggesting a link in diabetic vascular complications.

Area of Science:

  • Endocrinology
  • Hematology
  • Nephrology

Background:

  • Platelet activation and size are implicated in diabetic vascular complications.
  • Microalbuminuria is a key indicator of kidney damage in diabetes mellitus.

Purpose of the Study:

  • To investigate the association between mean platelet volume (MPV) and microalbuminuria in type 2 diabetic patients.
  • To determine if MPV levels differ among diabetic patients with and without microalbuminuria.

Main Methods:

  • Comparison of MPV levels between healthy controls and type 2 diabetic patients (with and without microalbuminuria).
  • Correlation analysis of MPV with clinical parameters including sex, diabetes duration, microalbuminuria, fasting blood glucose, HbA1c, creatinine clearance, and BMI.

Main Results:

  • Mean platelet volume levels were significantly higher in all diabetic patients compared to healthy controls.
  • Diabetic patients with microalbuminuria exhibited the highest MPV levels.
  • MPV showed a positive correlation with the presence of microalbuminuria.

Conclusions:

  • Diabetic patients, especially those with microalbuminuria, have elevated MPV.
  • MPV may be a relevant biomarker associated with microalbuminuria in type 2 diabetes.
  • Further research is warranted to explore the role of MPV in diabetic nephropathy pathogenesis.
Keywords:
Microalbuminuriamean platelet volumetype 2 diabetes mellitus

More Related Videos

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature05:54

Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature

Published on: January 24, 2025

760
Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy07:45

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy

Published on: December 30, 2025

615

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.3K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.8K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
295
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.7K
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
290
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
593