Related Experiment Video
Updated: Mar 16, 2026
05:08
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
4.7K
Nail changes in patients with inflammatory bowel diseases
Özlem Ekiz1, Ebru Çelik1, İlknur Balta2
1Department of Dermatology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Turkish Journal of Medical Sciences
|August 12, 2016
Summary
Nail changes are more common in patients with inflammatory bowel disease (IBD). This study identified specific nail alterations and fungal infections like onychomycosis in IBD patients compared to controls.
Area of Science:
- Gastroenterology
- Dermatology
- Clinical Medicine
Background:
- Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions affecting the gastrointestinal tract.
- Limited research exists on the spectrum of nail changes associated with IBD, excluding onychomycosis.
- This study investigates the prevalence and characteristics of nail abnormalities in IBD patients.
Purpose of the Study:
- To determine the frequency and patterns of nail changes in patients diagnosed with inflammatory bowel disease.
- To explore potential associations between nail alterations and various clinical parameters within the IBD cohort.
- To establish a baseline understanding of nail manifestations in IBD.
Main Methods:
- A comparative study involving 73 IBD patients and 51 healthy controls.
- Systematic examination of nails for color, texture, curvature, dystrophy, and pigmentation.
- Mycological assessments were conducted for suspected cases of onychomycosis.
Main Results:
- Nail changes were significantly more prevalent in the IBD group compared to the control group (P = 0.001).
- Onychomycosis occurred significantly more frequently in patients with IBD (P = 0.041).
- Subungual hyperkeratosis and brownish nail discoloration were the most frequently observed nail findings in IBD patients.
Conclusions:
- This research represents the first comprehensive report detailing diverse nail changes in inflammatory bowel disease.
- Further extensive research is warranted to elucidate the full spectrum and implications of nail abnormalities in IBD.
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.0K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.0K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.4K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K
01:17Chronic Bowel Disorders: Introduction
883
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
883
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
639
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
639
01:29Inflammatory Bowel Disease IV: Pharmacological Management
899
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
899