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Published on: April 28, 2020
The protective effect of Capparis ovata in acute hepatotoxicity induced by paracetamol
Nurcan Dogan1, Mustafa Akçam1, Tuğba Koca1
1Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine,Süleyman Demirel University, Isparta, Turkey.
Background/Aim:
To investigate the efficiency of Capparis ovata as a protective agent against acute paracetamol toxicity of the liver.
Materials And Methods:
A total of 36 Wistar albino rats were divided into 4 groups: 1) paracetamol, 2) Capparis ovata + paracetamol, 3) Capparis ovata, and 4) control. Groups 2 and 3 were given Capparis ovata and Groups 1 and 4 distilled water for 8 days. On day 8, 3000 mg kg-1 paracetamol was administered orally to Groups 1 and 2. Samples were taken on day 9. AST, ALT, total bilirubin, direct bilirubin, GGT, and ALP levels were assessed. Lipid peroxidation markers and thiobarbituric acid-reactive substance (TBARS) levels were measured in the blood and liver. Liver tissues were evaluated histologically.
Results:
AST, ALT, and total bilirubin levels were lower in Group 2 than in Group 1 (P < 0.05). TBARS levels were lower in Groups 2 (P = 0.000), 3 (P = 0.001), and 4 (P = 0.001) than in Group 1. Degenerative findings were lower in the Capparis ovata + paracetamol group than in the paracetamol group (P < 0.05).
Conclusion:
It can be concluded that Capparis ovata has a protective effect on the liver, both histopathologically and biochemically, against paracetamol-induced liver injury.
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