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Cholesteryl Ester Transfer Protein Inhibitors: Trials and Tribulations.
Julian Hardy McLain1, Andrew Jacob Alsterda1, Rohit R Arora2
11 Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
Journal of Cardiovascular Pharmacology and Therapeutics
|August 12, 2016
Summary
Cholesteryl ester transfer protein (CETP) inhibitors effectively modify cholesterol levels but show limited cardiovascular benefits. Further research is needed for effective cholesterol modification therapies.
Area of Science:
- Cardiovascular pharmacology and lipid metabolism.
Background:
- Cholesteryl ester transfer protein (CETP) facilitates lipid transfer between lipoproteins.
- CETP inhibitors were developed to target plasma cholesterol and reduce atherosclerotic cardiovascular disease risk, based on genetic correlations between CETP activity and cholesterol levels.
Purpose of the Study:
- To discuss the science of CETP inhibition.
- To compare developed CETP inhibitors (torcetrapib, evacetrapib, dalcetrapib, anacetrapib).
- To review findings from CETP inhibitor trials and discuss future outlook.
Main Methods:
- Review of scientific literature on CETP inhibitors.
- Analysis of genetic research linking CETP activity to cholesterol levels.
- Examination of data from Phase 3 outcome trials of CETP inhibitors.
Main Results:
- CETP inhibitors successfully alter targeted cholesterol markers.
- Recent Phase 3 trials indicate limited cardiovascular outcome benefits when used with standard care.
Conclusions:
- While effective cholesterol modifiers, CETP inhibitors have shown limited clinical benefit for cardiovascular outcomes.
- The future outlook for CETP inhibitors in cholesterol modification requires further investigation.
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