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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Author's reply

Jaswinder Ps Walia1, Bhupinder S Brar1, Anmol Sharma1

  • 1Department of Othopaedics, Government Medical College and Rajindra Hospital, Patiala, Punjab, India.

Indian Journal of Orthopaedics
|August 12, 2016
PubMed
Summary

No abstract available in PubMed .

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