Related Experiment Video

Updated: Mar 16, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

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Congenital cytomegalovirus infection: Clinical presentation, epidemiology, diagnosis and prevention

Wendy J van Zuylen1, Stuart T Hamilton2, Zin Naing1

  • 1Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia; School of Medical Sciences, University of New South Wales, Sydney, Australia.

Obstetric Medicine
|August 12, 2016
PubMed

Insights

Congenital cytomegalovirus (CMV) infection is a major cause of infant disability. Increased awareness and hygiene education are crucial for prevention, as effective treatments are lacking.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Public Health

Background:

  • Congenital cytomegalovirus (CMV) is the most common congenital infection.
  • It is the leading infectious cause of sensorineural hearing loss and neurodevelopmental disability in infants.
  • Limited awareness exists regarding congenital CMV infection among the public and medical professionals.

Purpose of the Study:

  • To review clinical features, epidemiology, transmission, and risk factors of CMV infections.
  • To highlight recent advances in diagnosis and prevention of maternal CMV infection.
  • To emphasize current strategies for preventing congenital CMV disease.

Main Methods:

  • Literature review of clinical features, global epidemiology, transmission, and risk factors.
  • Review of recent advances in diagnosis and prevention of CMV infection during pregnancy.
  • Synthesis of current knowledge on CMV infection management and prevention.

Main Results:

  • Cytomegalovirus is a significant cause of serious infant disease, including hearing loss and neurodevelopmental issues.
  • Recent advances have been made in diagnosing and preventing CMV infection during pregnancy.
  • No proven therapy currently exists to prevent or treat maternal, fetal, or neonatal CMV infection.

Conclusions:

  • Congenital CMV infection poses a substantial public health challenge due to its prevalence and severe consequences.
  • Enhanced diagnostic and preventive measures are emerging, but therapeutic options remain limited.
  • Education on hygiene practices is the most effective current strategy to prevent congenital CMV disease.

Keywords:
Infectioninfectious diseasesmaternal–fetal medicineneonatal medicine

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