Pregnancy outcomes in cystic fibrosis: a 10-year experience from a UK centre
M Renton1, L Priestley2, L Bennett2
1St John's College, University of Oxford, Oxford, UK.
Background:
Cystic fibrosis manifests as a multisystem disease, despite this female fertility is relatively preserved with levels approaching that of the non-cystic fibrosis population. We reviewed pregnancies in cystic fibrosis patients over a 10-year period from a UK adult cystic fibrosis centre by considering maternal and fetal outcomes.
Methods:
We conducted a retrospective case-note review of pregnancies during 2003-2013 using respiratory and obstetric records.
Results:
We observed moderate falls in lung function immediately after delivery, which persisted at 12 months postpartum. We found that a decline in lung function at delivery was a marker for further decline in function during the subsequent postpartum period. We found baseline lung function was predictive of gestational age at delivery. We observed a high incidence of haemoptysis.
Conclusion:
Consistent with current guidance we found pregnancy is feasible and well tolerated in the majority of patients with cystic fibrosis. There was a high incidence of haemoptysis, which warrants further study.
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