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Very high dose cis-platinum (450 mg/sq m) in an infant with rhabdomyosarcoma
1Department of Pediatric Hematology-Oncology, Giannina Gaslini Children's Hospital, Genova, Italy.
Anticancer Research
|March 1, 1989
Abstract:
The toxic effects of CDDP, erroneously given at 450 mg/sq m, are described. Life threatening gastrointestinal and myelotoxicity was observed as well as prolonged severe renal tubular acidosis without renal failure. No significant oto (brain-stem evoked responses) or neurotoxicity (EEG, neurologic examination and nerve conduction velocity) was detected indicating major age-related differences in the toxicity of this drug.