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Effects of resveratrol on the alterations of cavernosal eNOS and LOX-1 expression in the hypercholesterolemic

Ozan Bozkurt1, Aykut Kefi1, Ömer Demir1

  • 1Department of Urology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.

Turkish Journal of Medical Sciences
|August 12, 2016
PubMed
Abstract

Insights

Resveratrol supplementation improved endothelial nitric oxide synthase (eNOS) mRNA expression in hypercholesterolemic rabbits. This suggests a potential benefit for resveratrol in treating hypercholesterolemia-related erectile dysfunction.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Hypercholesterolemia can lead to endothelial dysfunction, affecting nitric oxide synthase (eNOS) expression.
  • Understanding the molecular mechanisms of hypercholesterolemia-induced erectile dysfunction is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the impact of resveratrol on cavernosal eNOS and LOX-1 mRNA expression in a hypercholesterolemic rabbit model.
  • To assess the potential therapeutic role of resveratrol in managing hypercholesterolemia-associated erectile dysfunction.

Main Methods:

  • New Zealand white male rabbits were divided into control, hypercholesterolemia, and resveratrol groups.
  • Hypercholesterolemia was induced with a 2% cholesterol diet for 6 weeks; resveratrol (4 mg/kg/day) was administered to the treatment group.
  • Cavernosal eNOS and LOX-1 mRNA expression levels were quantified using real-time RT-PCR.

Main Results:

  • Hypercholesterolemia significantly reduced eNOS mRNA expression compared to the control group (P = 0.011).
  • Resveratrol treatment normalized eNOS mRNA expression, showing levels similar to the control group and significantly higher than the hypercholesterolemia group (P < 0.001).
  • No significant difference in LOX-1 mRNA expression was observed across the three groups.

Conclusions:

  • Resveratrol demonstrates beneficial effects on cavernosal eNOS expression in hypercholesterolemic conditions.
  • This study provides the first evidence of cavernosal LOX-1 expression.
  • Resveratrol may serve as a potential therapeutic agent for hypercholesterolemic erectile dysfunction, warranting further investigation.
Keywords:
HypercholesterolemiaLOX-1eNOSerectile dysfunctionresveratrol

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