Total Synthesis of Anticancer Agent EBC-23
Dodda Vasudeva Reddy1, Gowravaram Sabitha, Tadikamalla Prabhakar Rao
1Academy of Scientific and Innovative Research (AcSIR) , New Delhi 110020, India.
Organic Letters
|August 12, 2016
Abstract:
Total synthesis of spiroketal EBC-23 has been described by two divergent approaches from three simple building blocks. Gold-catalyzed cycloisomerization of alkynol and acid-mediated spirocyclization of diketalketone were successfully utilized to effect spiroketal formation. A Cu(I)-P(Cy)3-catalyzed protocol for the highly regio- and stereocontrolled hydroboration of internal propargylic alcohol was effectively applied toward the β-hydroxy ketone via vinylboronates.
