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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
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Elena Guadalupe Corella Aznar1, Ariadna Ayerza Casas, Pilar Samper Villagrasa
1Hospital Infantil Miguel Servet. Zaragoza. elena_corella88@hotmail.com.
Nutricion Hospitalaria
|August 12, 2016
Summary
Childhood acute leukemia survivors face increased risks of obesity, dyslipidemia, insulin resistance, and hypertension. Aggressive treatments and poorer prognoses elevate these cardiometabolic risks, necessitating long-term monitoring.
Area of Science:
- Pediatric Oncology
- Cardiology
- Metabolic Disorders
Background:
- Childhood acute leukemia (AL) survivors have a higher risk of long-term metabolic and cardiovascular complications.
- These complications contribute significantly to increased morbidity and mortality in this population.
Purpose of the Study:
- To determine the prevalence of obesity, insulin resistance, dyslipidemia, and hypertension in childhood AL survivors.
- To identify associated risk factors for developing these cardiometabolic risks.
Main Methods:
- Retrospective observational study of 47 childhood AL survivors.
- Follow-up duration of 10 years post-treatment.
Main Results:
- 40% of survivors presented at least one cardiometabolic risk factor.
- Dyslipidemia (elevated LDL) was most frequent (38.3%), followed by overweight/obesity (31.9%) and systolic hypertension (23.4%).
- Female sex, poorer leukemia prognosis, hematopoietic stem cell transplantation, and radiotherapy were associated with increased cardiometabolic risks.
Conclusions:
- Childhood AL survivors exhibit a higher prevalence of obesity, dyslipidemia, insulin resistance, and systolic hypertension over time.
- More aggressive disease and treatments are linked to a greater risk of developing these adverse cardiometabolic outcomes.
