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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Structural Protein Function01:56

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Receptor Tyrosine Kinases01:26

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Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional

Smita Mohanty, Krishnadev Oruganty, Annie Kwon

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    Summary

    This study corrects a previous article DOI. The correction ensures accurate citation and retrieval of scientific information for researchers.

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    Area of Science:

    • Scientific publishing
    • Scholarly communication

    Context:

    • Correction of a published article's Digital Object Identifier (DOI).
    • Ensuring accurate referencing in scientific literature.

    Purpose:

    • To provide the correct DOI for the article.
    • To facilitate proper citation and access to the research.

    Summary:

    • The article DOI has been corrected to 10.1371/journal.pgen.1005885.
    • This ensures the integrity of the scientific record.

    Impact:

    • Improved discoverability of the corrected article.
    • Enhanced reliability of scientific databases and citation tracking.