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Updated: Mar 16, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Pemphigus foliaceus with circinated plaques and neutrophil pustules

Silvia Méndez-Flores1, Esperanza Avalos-Diaz2, Judith Dominguez-Cherit3

  • 1Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Mexico City, Mexico. silvia_mendezflores@live.com.mx.

Journal of Cutaneous Pathology
|August 13, 2016
PubMed

Insights

Pemphigus foliaceus (PF) typically presents with blisters. This study details a rare case of PF with pustules, expanding the known clinical features of this autoimmune blistering disease.

Area of Science:

  • Dermatology
  • Autoimmune diseases
  • Blistering disorders

Background:

  • Pemphigus is an autoimmune intraepidermal blistering disease.
  • Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are the most common subtypes.
  • Pustular variants of PF and PV are rarely documented.

Observation:

  • This manuscript presents an atypical case of pemphigus foliaceus (PF).
  • The case featured pustules, a less common clinical manifestation.
  • Clinical, microscopic, and immunologic findings were analyzed.

Findings:

  • Pemphigus foliaceus (PF) can present with pustules, not exclusively blisters.
  • This case expands the understanding of PF's clinical spectrum.
  • Literature review supports the rarity of pustular PF.

Implications:

  • Highlights the need to consider pustules in the differential diagnosis of pemphigus.
  • Enhances awareness of atypical presentations of pemphigus foliaceus.
  • Contributes to the understanding of autoimmune blistering disease variations.
Keywords:
autoantibodiesneutrophilic pustulespemphigus foliaceuspemphigus vulgaris

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