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The estrogen-related receptors (ERRs): potential targets against bone loss

Ling Zhang1,2, Jiemin Wong2, Jean-Marc Vanacker3

  • 1Institut de Génomique Fonctionnelle de Lyon, CNRS UMR5242, Université de Lyon, Université Lyon I, Ecole Normale Supérieure de Lyon, Lyon, France.

Cellular and Molecular Life Sciences : CMLS
|August 13, 2016
PubMed

Insights

Estrogen-related receptors (ERRs) alpha and gamma hinder bone formation. Inhibiting these receptors offers a new anabolic strategy to combat bone loss and skeletal fragility, particularly in post-menopause women.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Diseases

Background:

  • Bone loss and skeletal fragility are significant health issues, often linked to aging and estrogen deficiency in post-menopausal women.
  • Current treatments primarily focus on inhibiting bone resorption, leaving a need for anabolic strategies that promote bone formation.

Purpose of the Study:

  • To investigate the role of estrogen-related receptors (ERRs) alpha and gamma in bone formation.
  • To explore the potential of inhibiting ERRs as an anabolic therapeutic approach for bone loss.

Main Methods:

  • Review and summarization of existing data on estrogen-related receptors (ERRs) alpha and gamma.
  • Analysis of the impact of ERRs on bone formation processes.

Main Results:

  • Data indicate that estrogen-related receptors (ERRs) alpha and gamma actively prevent bone formation.
  • This suggests a novel mechanism by which these receptors influence skeletal health.

Conclusions:

  • Inhibition of estrogen-related receptors (ERRs) alpha and gamma presents a promising anabolic strategy to increase bone formation.
  • Targeting ERRs could offer a new therapeutic avenue for treating bone loss and preventing skeletal fragility.
Keywords:
BoneERRMenopauseNuclear receptorsOsteoblasts

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