[Effect of catamine AB on the generative function and chromosome apparatus of the bone marrow cells in white rats]

In a chronic experiment (6 months) performed on non-inbred white rats effect of cationic superficially active substance catamin AB on the structure and function of male and female gonads, state of the offspring and on the chromosome apparatus of the bone marrow cells has been studied. The preparation is intragastrically injected in doses 10, 1, 0.1 mg/kg. Catamin AB in the dose of 10 mg/kg produces an essential decrease in the specific mass of the testes, reduce in the spermatogenic index, increase in the canaliculi number with exfoliated epithelium, lowered mobility and diminished amount of alive spermatozoa. In the ovary amount of mature follicles becomes less and the number of atresic corpuscles and atresing follicles rises; plethora of the medullary substance occurs in the organ with signs of stasis in the venous bed. In the dose 1 mg/kg catamin AB results in less pronounced changes in the testes and does not produce any pathological disturbances in the ovaries. The preparation does not influence on mating in the test animals, but in the dose 10 mg/kg results in a decreasing fertility because of pre- and postimplantational death of embryos. The changes mentioned are connected with a total toxical effect of the preparation. Catamin AB does not possess any mutagenic effect in the doses tested.