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Primary orbital neuroblastoma.

J D Bullock1, S H Goldberg, S M Rakes

  • 1Department of Ophthalmology, Wright State University School of Medicine, Dayton, Ohio 45409.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|July 1, 1989
PubMed
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This case study details a rare adult primary orbital neuroblastoma. The patient achieved long-term remission after surgery and radiation therapy, highlighting a successful treatment outcome for this unusual tumor.

Area of Science:

  • Oncology
  • Ophthalmology
  • Pathology

Background:

  • Neuroblastoma is a pediatric cancer, rarely occurring in adults.
  • Primary orbital neuroblastoma is exceptionally rare, with few documented cases.
  • This study presents a unique case of adult orbital neuroblastoma.

Observation:

  • A 35-year-old man presented with primary neuroblastoma of the left orbit.
  • Histopathology revealed small round cells with characteristic neuroblastic features.
  • Immunohistochemistry and electron microscopy confirmed neuroblastoma diagnosis with dense core granules.

Findings:

  • The tumor exhibited nests, cords, pseudorosettes, and Homer-Wright rosettes.
  • Chromogranin staining was positive, consistent with neuroendocrine differentiation.

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  • The patient remained disease-free eight years post-treatment.

    • Implications:

    • This case expands the understanding of adult neuroblastoma presentation.
    • It underscores the possibility of successful outcomes with multimodal therapy in rare adult orbital tumors.
    • Further research into adult orbital neuroblastomas may be warranted.