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Related Experiment Video

Updated: Mar 16, 2026

Refined Murine Model of Idiopathic Pulmonary Fibrosis

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Published on: June 17, 2025

Pulmonary Alveolar Microlithiasis.

Atsushi Saito¹, Francis X McCormack²

¹Department of Biochemistry, Sapporo Medical University, School of Medicine, Sapporo 0608543, Japan; Department of Respiratory Medicine and Allergology, Sapporo Medical University, School of Medicine, Sapporo 0608556, Japan.

Clinics in Chest Medicine

|August 13, 2016

Summary

This summary is machine-generated.

Pulmonary alveolar microlithiasis (PAM) is a rare genetic lung disease causing calcium phosphate buildup. Research is exploring new treatments, with animal models showing promise for future clinical trials.

Keywords:

Congenital disease Phosphate homeostasis Pulmonary alveolar microlithiasis SLC34A2 Type II b sodium-phosphate cotransporter (NPT2B)

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Isolation and In Vitro Culture of Murine and Human Alveolar Macrophages

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Published on: April 20, 2018

Area of Science:

Pulmonary Medicine
Genetics
Rare Diseases

Background:

Pulmonary alveolar microlithiasis (PAM) is a rare genetic lung disorder.
Characterized by calcium phosphate deposits in lung alveoli.
Associated with mutations in the NPT2b gene.

Purpose of the Study:

To summarize the current understanding of Pulmonary alveolar microlithiasis.
To highlight the natural progression and clinical manifestations of PAM.
To discuss current and potential future treatment strategies.

Main Methods:

Review of existing literature on Pulmonary alveolar microlithiasis.
Analysis of genetic links, specifically NPT2b mutations.
Examination of disease progression and patient outcomes.

Main Results:

PAM is a progressive disease leading to dyspnea and respiratory insufficiency.
Current treatments are primarily supportive, focusing on oxygen therapy.
Lung transplantation is an option for end-stage disease.

Conclusions:

Pulmonary alveolar microlithiasis requires ongoing research for effective therapies.
Development of a laboratory animal model offers new avenues for treatment exploration.
Future clinical trials are anticipated based on promising preclinical findings.