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Updated: Mar 16, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Lymphocytic Interstitial Pneumonia
Tanmay S Panchabhai1, Carol Farver2, Kristin B Highland3
1Department of Medicine, Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Creighton University School of Medicine, Phoenix Regional Campus, 500 West Thomas Road, Suite 500, Phoenix, AZ 85013, USA.
Abstract:
Lymphocytic interstitial pneumonia (LIP) is a rare lung disease on the spectrum of benign pulmonary lymphoproliferative disorders. LIP is frequently associated with connective tissue diseases or infections. Idiopathic LIP is rare; every attempt must be made to diagnose underlying conditions when LIP is diagnosed. Computed tomography of the chest in patients with LIP may reveal ground-glass opacities, centrilobular and subpleural nodules, and randomly distributed thin-walled cysts. Demonstrating polyclonality with immunohistochemistry is the key to differentiating LIP from lymphoma. The 5-year mortality remains between 33% and 50% and is likely to vary based on the underlying disease process.
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