Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

8.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.6K
Mismatch Repair01:20

Mismatch Repair

6.9K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.9K
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

2.1K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
2.1K
Probability Laws01:49

Probability Laws

44.8K
Overview
44.8K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

11.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

European Reference Networks as core health structures where referring genetic newborn screening positive infants: an innovative operational research framework.

Frontiers in public health·2026
Same author

Hereditary cancer: Germline testing practices across ERN GENTURIS member countries.

European journal of human genetics : EJHG·2026
Same author

Personalized risk estimates of advanced neoplasia development in individuals with a family history of colorectal cancer.

Familial cancer·2026
Same author

Correction: Hereditary gynecological cancer management in women with Lynch syndrome: a survey across Europe.

Familial cancer·2026
Same author

Vaccine strategies for cancer prevention in Lynch syndrome: the potential of dendritic cell-based therapy.

Familial cancer·2026
Same author

Genome Sequencing of Undiagnosed European Patients Suspected of Hereditary Cancer: Diagnostic Yield and Identification of Candidate Causative Variants.

JCO precision oncology·2026

Related Experiment Video

Updated: Mar 16, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

15.1K

Finding all BRCA pathogenic mutation carriers: best practice models.

Nicoline Hoogerbrugge1, Marjolijn Cj Jongmans1

  • 1Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.

European Journal of Human Genetics : EJHG
|August 13, 2016
PubMed
Summary

Identifying germline BRCA pathogenic mutations is vital for breast and ovarian cancer patients and their families. Genetic testing allows for preventative measures and early cancer detection, improving treatment outcomes.

More Related Videos

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K
Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K

Related Experiment Videos

Last Updated: Mar 16, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

15.1K
gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
08:15

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair

Published on: October 6, 2014

12.7K
Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
09:22

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors

Published on: February 28, 2021

6.0K

Area of Science:

  • Oncology
  • Genetics
  • Medical Management

Background:

  • Germline BRCA pathogenic mutations are critical in managing breast and ovarian cancers.
  • Testing relatives of affected patients enables preventative strategies and early diagnosis.
  • BRCA mutation status influences treatment decisions, particularly in ovarian cancer.

Purpose of the Study:

  • To review best practices for genetic counselling and BRCA testing.
  • To examine challenges in current genetic counselling and BRCA testing practices.
  • To explore adapted models for genetic counselling to meet increased demand.

Main Methods:

  • Literature review on genetic counselling and BRCA testing in oncology.
  • Analysis of current challenges and adapted models for genetic counselling.
  • Discussion of the impact of BRCA mutation status on patient management and family testing.

Main Results:

  • Increased demand for BRCA testing due to its role in treatment decisions.
  • Need for updated genetic counselling approaches to accommodate higher testing volumes.
  • Identification of challenges in current genetic counselling practices.

Conclusions:

  • Best practices in genetic counselling and BRCA testing are essential.
  • Adapted models are necessary to address the growing demand for genetic services.
  • Optimizing genetic counselling ensures effective cancer prevention and management for patients and families.