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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

4.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.9K

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Related Experiment Video

Updated: Mar 16, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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DNA methylation dynamics: identification and functional annotation.

Hongbo Liu, Song Li, Xinyu Wang

    Briefings in Functional Genomics
    |August 13, 2016
    PubMed
    Summary

    DNA methylation dynamics, crucial for development and cancer, are increasingly studied. Advances in technology and computational tools enable genome-wide identification and functional annotation of these epigenetic changes.

    Keywords:
    DNA methylationDNA methylation dynamicsdemethylationfunctional annotationgene regulation

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    Area of Science:

    • Epigenetics and Molecular Biology
    • Genomics

    Background:

    • DNA methylation is a key epigenetic modification of cytosines.
    • It exhibits dynamic changes across time, space, and cell types.
    • Recent technological advancements allow high-throughput methylome profiling.

    Purpose of the Study:

    • To review state-of-the-art advances in DNA methylation dynamics.
    • To explore regulatory mechanisms and functional roles.
    • To provide future perspectives in the field.

    Main Methods:

    • Genome-wide identification of DNA methylation patterns.
    • Investigation of regulatory mechanisms governing methylation dynamics.
    • Functional annotation of DNA methylation in biological processes.

    Main Results:

    • High-throughput methylome profiling is now feasible.
    • Computational tools aid in analyzing DNA methylation dynamics.
    • DNA methylation dynamics are critical in development and cancer.

    Conclusions:

    • DNA methylation dynamics are central to transcriptional regulation.
    • Understanding these dynamics is vital for research in development and disease.
    • Continued research is needed to fully elucidate their roles.