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Rapid decrease of the peripheral deiodination of thyroxine in malabsorption syndrome in artificially inoculated
1Department of Physiology, University of Veterinary Science, Budapest, Hungary.
Abstract:
Thyroid function of broilers inoculated with the intestinal homogenate from birds from a field case of malabsorption syndrome was investigated during the first 2 days postinoculation. In one experiment, different amounts of the inoculum were applied to see if there exists a dose-response relationship. As early as 3 hours after inoculation, there was a significant drop in the serum level of triiodothyronine and in the activity of the liver 5'-deiodinase (type I). Type II deiodinase activity was less impaired. A minimum of 0.3 ml of inoculum was effective, whereas 0.05 ml of the same homogenate elicited a significant (P less than 0.01) drop in liver deiodinase activity. These findings underline the importance of thyroid impairment in the pathogenesis of malabsorption syndrome.