Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

354
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
354
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

419
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
419
Cancer Therapies02:49

Cancer Therapies

10.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.6K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

312
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
312
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

687
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
687

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A review of clinical trial radiotherapy quality assurance: value, evolution and lessons.

Clinical and translational radiation oncology·2026
Same author

Multi-institutional virtual peer review for reirradiation: dedicated workflow and one-year results.

Technical innovations & patient support in radiation oncology·2025
Same author

Dose escalation in pediatric pelvic Ewing's Sarcoma: Insights from a national treatment planning exercise.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Results of a phase Ib study of olaparib with concomitant radiotherapy in soft-tissue sarcoma: a French sarcoma group study.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Local relapse patterns after preoperative radiotherapy of limb and trunk wall soft tissue sarcomas: Prognostic role of imaging and pathologic response factors.

Clinical and translational radiation oncology·2024
Same author

Metabolic Profile of Cerebellum in Posterior Fossa Tumor Survivors: Correlation With Memory Impairment.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024

Related Experiment Video

Updated: Mar 16, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K

[Radiotherapy for paediatric cancers].

A Laprie1, L Padovani2, V Bernier3

  • 1Département de radiothérapie, institut Claudius-Regaud, institut universitaire du cancer de Toulouse-Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse, France; Université Paul-Sabatier Toulouse-III, 118, route de Narbonne, 31062 Toulouse, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|August 13, 2016
PubMed
Summary
This summary is machine-generated.

This article outlines paediatric radiation oncology, detailing cancer types, radiotherapy uses, techniques, and organizational and regulatory aspects for child cancer treatment.

Keywords:
Cancers de l’enfantCraniospinal irradiationEffets tardifsIrradiation craniospinaleLate effectsNephroblastomaNephroblastomeNeuroblastomaNeuroblastomePaediatric cancerRegulationRéglementation

More Related Videos

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.8K
Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.6K

Related Experiment Videos

Last Updated: Mar 16, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.2K
Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.8K
Whole-body PET/MRI of Pediatric Patients: The Details That Matter
10:02

Whole-body PET/MRI of Pediatric Patients: The Details That Matter

Published on: December 19, 2017

15.6K

Area of Science:

  • Oncology
  • Radiotherapy
  • Paediatric Medicine

Background:

  • Childhood cancers require specialized treatment approaches.
  • Radiation oncology plays a crucial role in managing paediatric malignancies.

Purpose of the Study:

  • To delineate the unique characteristics of paediatric radiation oncology.
  • To cover cancer types, radiotherapy indications, techniques, and organizational/regulatory frameworks.

Main Methods:

  • Literature review of paediatric radiation oncology practices.
  • Synthesis of information on cancer types and treatment indications.
  • Description of radiotherapy techniques and organizational structures.

Main Results:

  • Identification of common paediatric cancers treated with radiotherapy.
  • Overview of specific radiotherapy indications in children.
  • Explanation of specialized techniques and organizational models.

Conclusions:

  • Paediatric radiation oncology presents distinct challenges and requirements.
  • A comprehensive understanding of these specificities is vital for effective treatment and research.