Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium Poisoning.

Jonathan Baird-Gunning1,2, Tom Lea-Henry3, Lotte C G Hoegberg4

  • 11 Department of General Medicine, The Canberra Hospital, Garran, Australian Capital Territory, Australia.

Journal of Intensive Care Medicine
|August 13, 2016
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dental Students' Perceptions of Preheated Resin Composite Use for Direct Restorations and Indirect Luting Procedures.

European journal of dental education : official journal of the Association for Dental Education in Europe·2026
Same author

Pork meat quality profile from pigs originating from two different production streams with and without antibiotics administered at weaning.

Meat science·2026
Same author

A comprehensive overview of paracetamol poisoning admissions and long-term outcomes in New South Wales, Australia: a retrospective linked data cohort (PAVLOVA-3).

The Lancet regional health. Western Pacific·2026
Same author

Glucagon-like peptide-1 agonists for treating substance use disorders: ready for clinical use?

Internal medicine journal·2026
Same author

Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose.

Clinical toxicology (Philadelphia, Pa.)·2026
Same author

AusVapeSafety: a prospective observational study of vape exposures and outcomes to an Australian Poisons Information Centre.

Clinical toxicology (Philadelphia, Pa.)·2026
This summary is machine-generated.

Lithium toxicity poses risks due to its narrow therapeutic index and kidney function impact. Careful monitoring and understanding poisoning patterns are crucial for managing bipolar disorder patients effectively.

Area of Science:

  • Pharmacology
  • Nephrology
  • Neurology

Background:

  • Lithium is a key treatment for bipolar disorder.
  • Its narrow therapeutic index and kidney function influence necessitate careful management to prevent toxicity.
  • Understanding lithium poisoning patterns (acute, acute-on-chronic, chronic) is vital for treatment.

Purpose of the Study:

  • To review lithium poisoning, focusing on its causes, clinical manifestations, and management strategies.
  • To discuss the role and evidence for extracorporeal treatments in managing lithium toxicity.

Main Methods:

  • Literature review of lithium poisoning, its pathophysiology, and treatment modalities.
  • Analysis of clinical presentations and outcomes associated with different poisoning patterns.
Keywords:
continuous renal replacement therapyenhanced eliminationextracorporeal treatmentintermittent hemodialysisneurotoxicitysodium polystyrene sulfonatesyndrome of irreversible lithium effectuated neurotoxicity

Related Experiment Videos

  • Evaluation of the current evidence for extracorporeal treatments like dialysis.

    • Main Results:

    • Chronic lithium poisoning, often unintentional, is common and linked to impaired kidney function.
    • Central nervous system effects are primary, ranging from asymptomatic levels to severe neurological deficits.
    • Lithium is dialyzable, but evidence for extracorporeal treatments is largely observational, lacking randomized controlled trials.

    Conclusions:

    • Careful dosing, monitoring, and titration are essential for safe lithium use.
    • Further research, including randomized controlled trials, is needed to clarify the benefits and optimal use of extracorporeal treatments for lithium poisoning.