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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Chronic hepatitis E - an emerging disease in an immunocompromised host
Amitabh Singh1, Rachna Seth1, Anand Gupta1
1Department of Paediatrics, All India Institute of Medical Sciences, New Delhi, India.
Abstract:
Chronic hepatitis E virus (HEV) infection is increasingly being reported in immunosuppressed individuals with HIV, patients with haematological malignancy and transplant recipients. The diagnosis of cirrhosis and liver failure post chronic HEV is controversial due to lack of standard diagnostic criteria. The treatment benefits of ribavirin in chronic HEV of genotype 1 are not well reported. We report a case of chronic HEV infection of genotype 1 leading to chronic liver disease in a child cured of acute leukaemia. Our report also highlights the successful use of ribavirin for eradicating chronic HEV infection and its subsequent survival benefits. Chronic hepatitis E may be an emerging disease of immunosuppressed patients and should be suspected in the presence of cryptogenic transaminitis. Ribavirin is an effective therapy for controlling HEV.
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