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FloWave.US: validated, open-source, and flexible software for ultrasound blood flow analysis
Crystal L Coolbaugh1, Emily C Bush2, Charles F Caskey3
1Vanderbilt University Institute of Imaging Science, Nashville, Tennessee; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee; crystal.coolbaugh@vanderbilt.edu.
FloWave.US is new open-source software that automates ultrasound blood flow analysis, offering accuracy, speed, and flexibility. This tool enhances measurements of blood velocity, vessel diameter, and flow, outperforming manual methods.
Area of Science:
- Biomedical Engineering
- Medical Imaging
Background:
- Automated ultrasound software enhances blood flow analysis accuracy.
- Existing software lacks customization and validation flexibility.
Purpose of the Study:
- Develop FloWave.US, an open-source software for automated ultrasound blood flow analysis.
- Validate its accuracy and compare it with manual methods.
Main Methods:
- Developed FloWave.US open-source software.
- Validated measures using a skeletal muscle ultrasound flow phantom.
- Compared FloWave.US with commercial manual analysis software in vivo.
Main Results:
- Achieved low aggregate relative error for blood velocity (4.32%) and vessel diameter (0.31%).
- Demonstrated equivalent in vivo TAMean velocities compared to manual analysis (mean bias <1 pixel).
- Automated analysis was 9.8 times faster than manual methods.
Conclusions:
- FloWave.US offers accurate, reliable, and flexible automated ultrasound blood flow analysis.
- The software reduces processing time and is cost-effective.
- Open-source availability facilitates customization for various vascular physiology applications.
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