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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
Published on: March 13, 2018
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Background review for diagnostic test development for Zika virus infection
Rémi N Charrel1, Isabelle Leparc-Goffart2, Suzan Pas3
1UMR EPV Emergence des Pathologies Virales, Aix Marseille Université, Marseille, France.
Bulletin of the World Health Organization
|August 13, 2016
Summary
Urgent research is needed to improve Zika virus diagnostic testing. This includes assessing lab capacity, validating tests in the field, and monitoring viral diversity to address knowledge gaps.
Area of Science:
- Virology
- Infectious Diseases
- Diagnostic Medicine
Background:
- Zika virus poses a significant public health threat, necessitating accurate diagnostic tools.
- Current diagnostic capabilities for Zika virus infection require further evaluation and enhancement.
Purpose of the Study:
- To review the current state of knowledge regarding Zika virus diagnostic testing.
- To identify critical research areas to address existing knowledge gaps in Zika virus diagnostics.
Main Methods:
- A non-systematic literature review of Zika virus research.
- Inclusion of data from commercial diagnostic test kits and expert communications.
- Discussion of molecular and serological tests in the context of the current outbreak strain.
Main Results:
- Urgent assessment of global laboratory capacity for Zika virus detection is required.
- Field validation of molecular and serological tests, especially for pregnant women, is crucial.
- Monitoring genomic diversity and understanding virus infection kinetics are essential research priorities.
Conclusions:
- An international, coordinated laboratory response is necessary for effective Zika virus diagnostics.
- Development of protocols for prospective studies is needed to address pressing information requirements.
