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Updated: Mar 16, 2026

Determination of the Gas-phase Acidities of Oligopeptides
Published on: June 24, 2013
The Determination of Protonation Constants of Peptidomimetic Cyclophanes in Binary Methanol-Water Mixtures
Piotr Seliger1, Danuta Tomczyk1, Grzegorz Andrijewski1
1Department of Inorganic and Analytical Chemistry, University of Lodz, Tamka 12, 91-403 Lodz, Poland.
Abstract:
The protonation constants of new group of peptidomimetic cyclophanes with valine or phenylalanine moieties incorporated into the macrocyclic skeleton as well as their linear analogues were determined by potentiometric measurements in solutions of methanol-water mixtures at 25°C and constant ionic strength. The influence of cavity size, location of protonation sites, and attached substituents of the macrocyclic ligands on the protonation constants were discussed on the basis of potentiometric measurement as well as H(1)-NMR results.
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