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Articles linked to this work by shared authors, journal, and citation graph.

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Effect of phenytoin therapy on thyroid function.

British journal of clinical pharmacology·2012
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Thyrotropin releasing hormone and the lower oesophageal sphincter.

Irish journal of medical science·1980
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Effects of chronic renal disease on thyroid hormone metabolism.

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Thyroid function in non-thyroidal illness.

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A rapid and simple method for simultaneous measurement of serum free thyroxine and triiodothyronine fractions.

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Random urine tests in the assessment of thyroid function.

J F Finucane1

  • 1Department of Medicine, Queen Elizabeth Hospital, Birmingham.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary
This summary is machine-generated.

Measuring urine thyroxine and triiodothyronine is not a reliable method for assessing thyroid status. While it can distinguish hyperthyroid patients, it shows overlap with normal and hypothyroid ranges.

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Area of Science:

  • Endocrinology
  • Clinical Chemistry

Background:

  • Thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are crucial for metabolism.
  • Assessing thyroid function typically involves serum hormone levels.

Purpose of the Study:

  • To evaluate the utility of measuring unconjugated thyroxine and triiodothyronine in random urine samples for assessing thyroid status.
  • To compare urinary hormone levels across normal subjects, thyroid disease patients, and those with conditions affecting thyroid function tests.

Main Methods:

  • Highly specific assays were used to measure unconjugated T4 and T3 in random urine samples.
  • Hormone concentrations were standardized using the simultaneously determined creatinine concentration.
  • Subjects included normal individuals, patients with thyroid disease, and euthyroid patients with confounding clinical conditions.

Main Results:

  • Urinary excretion of T4 and T3 was relatively constant throughout the day in individuals.
  • Thyrotoxic patients were clearly distinguishable from normal subjects based on urinary T4 or T3.
  • Significant overlap was observed between normal and hypothyroid urinary hormone values.
  • Elevated urinary T4 was noted in patients with proteinuria, pregnancy, and phenytoin treatment.
  • Many euthyroid patients exhibited T3 values outside the normal range.

Conclusions:

  • Measurement of unconjugated thyroxine and triiodothyronine in random urine specimens has limited value for assessing thyroid status.
  • Urinary hormone levels can be influenced by various physiological and pathological conditions, complicating interpretation.
  • Further research may be needed to explore specific applications or refine interpretation of urinary thyroid hormone measurements.