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Circulating immunoreactive substance P in man.

P Skrabanek1,2,3, D Cannon1,2,3, J Kirrane1,2,3

  • 1Department of Endocrinology, Mater Misericordiae Hospital, Dublin.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary
This summary is machine-generated.

Plasma levels of immunoreactive substance P (iSP) were measured in healthy individuals and patients. iSP is degraded by the liver, showing transient decreases during stress and episodic bursts during sleep, independent of kidney function.

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Area of Science:

  • Neuroendocrinology
  • Clinical Chemistry

Background:

  • Substance P is a neuropeptide with diverse physiological roles.
  • Understanding its circulating levels and regulation is crucial for clinical applications.

Purpose of the Study:

  • To measure plasma immunoreactive substance P (iSP) in normal subjects and hospital patients.
  • To investigate factors affecting iSP degradation and its in vivo regulation.
  • To explore the relationship between iSP levels and physiological conditions like hypoglycemia and sleep.

Main Methods:

  • Measurement of plasma iSP in 77 normal subjects and 125 hospital patients.
  • In vitro studies on iSP degradation.
  • Observation of iSP levels during insulin-induced hypoglycemia and glucose-tolerance tests.
  • Monitoring of iSP in sleeping volunteers and a patient with carcinoid metastases.

Main Results:

  • Plasma iSP levels were measured in a large cohort.
  • In vivo iSP degradation occurs in the liver, independent of renal function.
  • Transient decreases in plasma iSP were observed during hypoglycemic stress.
  • Episodic secretory bursts of iSP were detected during sleep, not circadian rhythm.
  • An elevated iSP level with a hepatic gradient was noted in a patient with liver carcinoid metastases.

Conclusions:

  • Hepatic degradation is the primary route for iSP clearance.
  • Plasma iSP levels are influenced by metabolic stress and sleep patterns.
  • Further research into iSP's role in neuroendocrine regulation and disease states is warranted.