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2-substituted derivatives of benzimidazole inhibiting gastric acid secretion in rats
A Pinelli1, S Trivulzio, L Malvezzi
1Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy.
Arzneimittel-Forschung
|April 1, 1989
Abstract:
Benzimidazole and its 2-derivatives with amino, carbamonitrile, urea, and guanidine groups have been tested for their activity on gastric secretory process. The carbamonitrile-, urea-, and guanidine compounds decrease gastric acid secretion, basal and stimulated with histamine or betazole, in Shay-rats and depress the guinea pig auricle activity stimulated by betazole. The results suggest that the studied 2-substituted benzimidazole compounds exhibit anti H2-histamine activity.