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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.6K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Related Experiment Video

Updated: Mar 16, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Atopic Dermatitis: Update for Pediatricians.

Katherine Grey, Sheilagh Maguiness

    Pediatric Annals
    |August 13, 2016
    PubMed
    Summary

    Early emollient use in infants may prevent atopic dermatitis (AD), a common inflammatory skin condition. This approach addresses skin barrier dysfunction, a key factor in AD development and severity.

    Area of Science:

    • Dermatology
    • Pediatrics
    • Genetics

    Background:

    • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition affecting up to 20% of children.
    • Skin barrier dysfunction is increasingly recognized as central to AD pathogenesis.
    • Filaggrin gene mutations are a significant predisposing factor for AD development.

    Purpose of the Study:

    • To review current understanding of atopic dermatitis pathogenesis and management.
    • To highlight the role of skin barrier function and genetic factors.
    • To discuss preventative strategies for AD.

    Main Methods:

    • Literature review of recent advances in atopic dermatitis research.
    • Analysis of the role of filaggrin in epidermal barrier maintenance.

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  • Evaluation of treatment strategies for eczema symptoms.

    • Main Results:

    • Genetic defects in filaggrin compromise the epidermal barrier, increasing AD risk.
    • Effective AD management involves emollients, anti-inflammatory agents, and infection control (e.g., diluted bleach baths).
    • Emerging evidence suggests early emollient application from birth can prevent AD onset.

    Conclusions:

    • Addressing skin barrier dysfunction is crucial for managing and potentially preventing atopic dermatitis.
    • A multi-faceted approach including emollients, anti-inflammatories, and infection control is recommended for AD treatment.
    • Proactive skincare, such as early emollient use, shows promise in preventing AD in infants.