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Comparative investigation of the antiproliferative efficacy of alclometasone
D Lubach1, M Kietzmann, Y Neumann
1Department of Dermatology (Hautklinik Linden), Medizinische Hochschule Hannover, Fed. Rep. of Germany.
Abstract:
In this study, the antiproliferative activity of a 0.05% alclometasone ointment (Alc, Delonal) on the epidermis of the mouse tail was investigated. We have found that Alc thins the epidermis to approximately the same extent as hydrocortisone acetate (1%), but has an extremely slighter epidermal thinning effect than betamethasone (betametasone-17,21-dipropionate, 0.064%, Diprosis). The incorporation rate of 3H-thymidine triphosphate into the DNA was inhibited to almost the same extent. In conclusion the small antiproliferative effect of Alc shows no correlating effects compared with its high vasoconstrictory efficacy.