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Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
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Myxoedema coma.

M J Cullen1,2, P D Mayne1,2, I Sliney1,2

  • 1The Department of Clinical Medicine, Trinity College, Dublin.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary
This summary is machine-generated.

Three patients with severe hypothyroidism, including two in myxedema coma, survived due to modern intensive care. Lifelong treatment adherence is crucial for managing hypothyroidism and preventing coma.

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Area of Science:

  • Endocrinology
  • Internal Medicine

Background:

  • Profound hypothyroidism can lead to life-threatening myxedema coma.
  • Patient non-adherence to medication is a significant factor in recurrent hypothyroidism and coma.
  • Modern intensive care has improved outcomes for myxedema coma patients.

Purpose of the Study:

  • To report three cases of profound hypothyroidism, two of whom presented with myxedema coma.
  • To highlight the importance of lifelong treatment adherence for hypothyroidism.
  • To present findings from hypothalamic-pituitary dynamic studies.

Main Methods:

  • Case series reporting three patients with profound hypothyroidism.
  • Inclusion of intensive care management strategies.
  • Performance of hypothalamic-pituitary dynamic studies using thyrotropin-releasing hormone (TRH) and luteinizing hormone-releasing hormone (LHRH).

Main Results:

  • All three patients with profound hypothyroidism survived.
  • Two patients recovered from myxedema coma with intensive care.
  • Hypothalamic-pituitary function was assessed via TRH and LHRH stimulation tests.

Conclusions:

  • Intensive care improves survival rates in myxedema coma.
  • Patient and family education on the necessity of lifelong hypothyroidism treatment is vital.
  • Understanding hypothalamic-pituitary dynamics is important in managing severe hypothyroidism.